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KMID : 0878220080200020098
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Journal of Sasang Constitutional Medicine
2008 Volume.20 No. 2 p.98 ~ p.110
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Anti-aging Effects of Sipyimigwanjung-tang in Aged Rats
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Sun Teh-Cheng
Ahn Taek-Won
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Abstract
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Objectives : The purpose of this study is to prove the anti-aging effects of Sipyimigwanjung-tang.
Methods : The SD rats used in this experiment were 6, 18 and 36 weeks old. A part of the 36weeks was grown to 52 and 68 weeks at labarotary. Each age group was again divided into three groups. These 15 groups consisted of 6 rats each. One group was given no treatment, another group was dosed 200 of normal saline daily, and the last group was dosed 200 of 1% Sipyimigwanjung-tang(SYG) and saline mixture. At the conclusion of the experiment, the age groups were relabelled accordingly(10w, 22w, 40w, 52w and 68w). After 4 weeks, the tissue of liver, heart, spleen, lung, kidney and brain was biopsied in order to measure the SOD, GSH, MDA.
Results and Conclusions : In liver, the activity of the SOD of 52w-SYG was significantly increased than that of 10w, 22w and 40w-SYG, the level of the GSH of 40w-SYG was significantly increased than that of the normal group, the activity of the catalase of 68w-SYG was significantly increased than that of the normal and control group, the level of the MDA of 52w-SYG and 68w-SYG was significantly decreased than that of the normal and control groups. In heart, the level of the GSH of 22w-SYG was significantly increased than that of the normal and control group. In spleen, the level of the GSH of 52w-SYG was significantly increased than that of the normal and control group. In lung, the level of the GSH of 52w-SYG was significantly increased than that of the normal group and the level of 68w-SYG was significantly increased than that of the normal and control group. In kidney, the level of the GSH of 10w-SYG was significantly increased than that of the normal group. In brain, the level of the GSH of 68w-SYG was significantly increased than that of the normal and control group. The SYG inhibited the histology degeneration of brain tissue. These results suggest that oral administration of SYG (Sipyimigwanjung-tang) decoction has anti-aging effects in aged rats.
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KEYWORD
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Sipyimigwanjung-tang, Anti-aging Effect, SOD, GSH
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